I've been looking pygame versus pyglet and hoping to find a ready-to-use accelerated sprite library. Although I really want to write a straight Python, installable game, the lure of the web is strong. There are a lot of fun ideas I could try there, and probably a much larger audience I would reach. Of course, there are pros and cons to both.
My options really aren't very clear. I don't know which I'll go with. Either way, I'm sure I'll bring Python into the mix on some level. Of course, I don't necessarily have to choose one or the other. I'm considering the option of taking both routes. The development time would take longer, but I could try an interesting approach of a demo or slim version of the game for free use, probably supported with advertising. Anyone who enjoys the game enough can buy a full version for download.
There are even techniques to share a significant amount of the development effort between the two versions. I'm sure that would give me some interesting things to blog about and perhaps some fun pieces of code to share.